In addition to acting, Jonathan Jackson plays guitar and sings in a band with his brother, Richard Lee. The band is called Enation, and they have released several albums and had a Top 10 hit on the iTunes national Rock Charts. Jonathan and Richard Lee played under various names before forming Enation, such as Jono and the Rock, Scarlet River and Scarlet Road. Several of the band's songs were aired on General Hospital, the most memorable being his ballad "Elizabeth". Most recently, a song by Enation titled "Feel This" was prominently featured on the television series One Tree Hill, which stars Enation member Michael Galeotti's wife Bethany Joy Galeotti. He had a recurring role as Kyle Reese in the hit Fox TV show Terminator: The Sarah Connor Chronicles, playing the father of John Connor before the show was cancelled. In 2009, he will star in the feature film thriller Kalamity, alongside Nick Stahl.

It's been years literally since Jonathan Jackson played the role of Lucky Spencer on General Hospital. With the promoted exit of Greg Vaughn, Jonathan is ready to take back the role. Filming with Jonathan on the GH set has started this Thursday. One thing is for sure, Jackson has certainly "Grown Up". Jonathan Jackson was born in Orlando, Florida, he is the son of Jeanine, an office manager, and Dr. Rick Jackson, a family practitioner, musician, and Congressional candidate in the state of Washington. Jon was raised in Washington, and has two siblings. His older brother, Richard Lee, is also an actor and the drummer in their band, Enation. His older sister, Candice, is a lawyer and a best selling author. He is also politically active. He campaigned for Mike Huckabee in 2008 and served as part of the Hollywood A Team for George W. Bush in his 2000 Presidential Campaign. He married former General Hospital actress Lisa Vultaggio on June 21, 2002. They have a son, Caleb, born on June 21, 2003 and a daughter, Adora, born in the summer of 2005. The family splits their time between Washington and Los Angeles.

It was announced on September 29, 2009 that Jackson will return to General Hospital to portray the role of Lucky Spencer, beginning October 27.